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Minoru Hasegawa Selected Research

Transforming Growth Factor beta (TGF-beta)

1/2010B lymphocytes: shedding new light on the pathogenesis of systemic sclerosis.
11/2009A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis.
8/2009CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling.
7/2004Augmented production of transforming growth factor-beta by cultured peripheral blood mononuclear cells from patients with systemic sclerosis.

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Minoru Hasegawa Research Topics

Disease

75Systemic Scleroderma (Systemic Sclerosis)
08/2022 - 06/2002
40Fibrosis (Cirrhosis)
05/2024 - 06/2002
15Dermatomyositis (Dermatopolymyositis)
10/2023 - 04/2003
15Pulmonary Fibrosis (Fibrosing Alveolitis)
05/2011 - 11/2002
13Neoplasms (Cancer)
12/2022 - 04/2011
13Systemic Lupus Erythematosus (Libman-Sacks Disease)
05/2011 - 04/2003
12Sclerosis
07/2021 - 06/2002
10Inflammation (Inflammations)
05/2024 - 03/2002
10Autoimmune Diseases (Autoimmune Disease)
06/2013 - 10/2005
7Pain (Aches)
04/2019 - 09/2009
7Hemorrhage
11/2012 - 03/2002
6Myositis (Idiopathic Inflammatory Myopathies)
10/2023 - 02/2012
6Interstitial Lung Diseases (Interstitial Lung Disease)
10/2020 - 04/2011
5Bronchiolitis Obliterans Syndrome
05/2024 - 12/2012
5Psoriasis (Pustulosis Palmaris et Plantaris)
06/2021 - 05/2004
5Pulmonary Arterial Hypertension
10/2020 - 01/2006
5Hypersensitivity (Allergy)
02/2016 - 04/2003
5Arthus Reaction
09/2012 - 03/2002
5Contact Dermatitis (Eczema, Contact)
06/2010 - 04/2003
5Localized Scleroderma (Morphea)
10/2008 - 01/2003
5Bullous Pemphigoid (Pemphigoid)
03/2008 - 06/2006
4Melanoma (Melanoma, Malignant)
10/2022 - 01/2012
4Disease Progression
10/2020 - 11/2013
4Hyperalgesia
08/2018 - 09/2009
4Rheumatoid Arthritis
06/2017 - 02/2007
4Bone Neoplasms (Bone Cancer)
04/2015 - 09/2009
4Cicatrix (Scar)
09/2013 - 06/2004
4Wounds and Injuries (Trauma)
04/2013 - 09/2007
4Atopic Dermatitis (Atopic Eczema)
03/2008 - 04/2003
3Erythema
10/2023 - 12/2005
3Constipation
01/2021 - 01/2011
3Opioid-Induced Constipation
09/2020 - 01/2019
3Diarrhea
01/2020 - 07/2017
3Chronic Pain
04/2019 - 01/2013
3Neuralgia (Stump Neuralgia)
08/2018 - 09/2009
3digital ulcers
09/2015 - 06/2009
3Lung Injury
09/2011 - 11/2002
3Diffuse Scleroderma (Progressive Systemic Sclerosis)
04/2010 - 04/2003
3Edema (Dropsy)
01/2010 - 03/2002
3Ulcer
05/2009 - 12/2005
3Connective Tissue Diseases (Connective Tissue Disease)
03/2008 - 10/2005
3Pemphigus (Pemphigus Vulgaris)
09/2007 - 06/2006
2Graft vs Host Disease (Graft-Versus-Host Disease)
05/2024 - 01/2008

Drug/Important Bio-Agent (IBA)

30AutoantibodiesIBA
10/2023 - 06/2002
26CytokinesIBA
03/2024 - 11/2002
15Immunoglobulin G (IgG)IBA
10/2023 - 12/2002
13ChemokinesIBA
10/2020 - 06/2004
13Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
07/2014 - 03/2002
12Bleomycin (Blenoxane)FDA LinkGeneric
01/2023 - 11/2002
12Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2020 - 03/2002
11EnzymesIBA
10/2023 - 04/2003
11AntibodiesIBA
01/2023 - 12/2005
11Interleukin-6 (Interleukin 6)IBA
01/2016 - 06/2002
11L-SelectinIBA
07/2014 - 03/2002
9Morphine (MS Contin)FDA LinkGeneric
09/2020 - 09/2009
9AntigensIBA
01/2018 - 07/2005
7CollagenIBA
01/2018 - 04/2003
7anti-scl-70 autoantibodiesIBA
01/2017 - 06/2004
7P-SelectinIBA
01/2016 - 09/2006
6Indicators and Reagents (Reagents)IBA
08/2021 - 09/2005
6Opioid Analgesics (Opioids)IBA
01/2021 - 09/2009
6Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA
10/2020 - 06/2004
6ImmunosorbentsIBA
04/2015 - 04/2003
6Oxycodone (Oxycontin)FDA LinkGeneric
04/2015 - 09/2009
5Biomarkers (Surrogate Marker)IBA
10/2020 - 05/2011
5Analgesics (Analgesic Drugs)IBA
04/2019 - 09/2009
5LigandsIBA
05/2018 - 03/2008
5Immunoglobulin M (IgM)IBA
12/2012 - 01/2004
5E-SelectinIBA
08/2010 - 09/2006
4Monoclonal AntibodiesIBA
05/2024 - 09/2006
4Opioid Receptors (Opioid Receptor)IBA
01/2021 - 01/2013
4naldemedineIBA
01/2021 - 01/2019
4Glycoproteins (Glycoprotein)IBA
01/2016 - 09/2007
4Proteins (Proteins, Gene)FDA Link
07/2014 - 02/2011
4Type I DNA Topoisomerases (Topoisomerase I)IBA
09/2013 - 01/2004
4Chemotactic FactorsIBA
04/2013 - 07/2003
4Antigen-Antibody Complex (Immune Complex)IBA
09/2012 - 05/2007
4Transforming Growth Factor beta (TGF-beta)IBA
01/2010 - 07/2004
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
05/2024 - 12/2012
3Chemokine CX3CL1IBA
05/2024 - 05/2004
3SteroidsIBA
10/2023 - 09/2003
3Rituximab (Mabthera)FDA Link
08/2022 - 10/2005
3Connective Tissue Growth FactorIBA
11/2019 - 11/2012
3Prednisolone (Predate)FDA LinkGeneric
04/2019 - 08/2004
3Transforming Growth Factors (Transforming Growth Factor)IBA
01/2018 - 01/2012
3Messenger RNA (mRNA)IBA
01/2018 - 03/2013
3AutoantigensIBA
11/2017 - 06/2002
3InterferonsIBA
11/2014 - 02/2011
3Interleukin-10 (Interleukin 10)IBA
06/2013 - 08/2008
3Immunoglobulins (Immunoglobulin)IBA
12/2012 - 05/2009
3Interleukin-4 (Interleukin 4)IBA
11/2012 - 06/2008
3Interleukin-17 (Interleukin 17)IBA
11/2012 - 06/2008
3Immunoglobulin E (IgE)IBA
09/2012 - 06/2009
3trioctyl phosphine oxide (TOPO)IBA
01/2010 - 01/2004
3Hyaluronic Acid (Hyaluronan)IBA
08/2009 - 06/2008
3B-Cell Activating FactorIBA
03/2008 - 02/2007
3SelectinsIBA
09/2007 - 09/2006
2Intravenous Immunoglobulins (IVIG)FDA Link
10/2023 - 04/2006
2UbiquitinIBA
10/2023 - 01/2013

Therapy/Procedure

15Therapeutics
05/2024 - 04/2006